Plasmonic Nanodiamonds: Targeted Core-Shell Type Nanoparticles for Cancer Cell Thermoablation

0443671 - ÚOCHB 2016 RIV GB eng J - Journal Article
Řehoř, Ivan - Lee, K. L. - Chen, K. - Hájek, Miroslav - Havlík, Jan - Lokajová, Jana - Mašát, Milan - Šlegerová, Jitka - Shukla, S. - Heidari, H. - Bals, S. - Steinmetz, N. F. - Cígler, Petr
Plasmonic Nanodiamonds: Targeted Core-Shell Type Nanoparticles for Cancer Cell Thermoablation.
Advanced Healthcare Materials. Roč. 4, č. 3 (2015), s. 460-468. ISSN 2192-2640. E-ISSN 2192-2659
R&D Projects: GA ČR GAP108/12/0640; GA MŠMT(CZ) LH11027; GA MŠMT LO1302
Grant - others:OPPC(CZ) CZ.2.16/3.1.00/24016
Institutional support: RVO:61388963
Keywords : nanodiamonds * plasmonics * gold * cancer * ablation
Subject RIV: CC - Organic Chemistry
Impact factor: 5.760, year: 2015

Targeted biocompatible nanostructures with controlled plasmonic and morphological parameters are promising materials for cancer treatment based on selective thermal ablation of cells. Here, core-shell plasmonic nanodiamonds consisting of a silica-encapsulated diamond nanocrystal coated in a gold shell are designed and synthesized. The architecture of particles is analyzed and confirmed in detail using electron tomography. The particles are biocompatibilized using a PEG polymer terminated with bioorthogonally reactive alkyne groups. Azide-modified transferrin is attached to these particles, and their high colloidal stability and successful targeting to cancer cells overexpressing the transferrin receptor are demonstrated. The particles are nontoxic to the cells and they are readily internalized upon binding to the transferrin receptor. The high plasmonic cross section of the particles in the near-infrared region is utilized to quantitatively ablate the cancer cells with a short, one-minute irradiation by a pulse 750-nm laser.
Permanent Link: http://hdl.handle.net/11104/0246380