Lipid signaling in adipose tissue: Connecting inflammation & metabolism

0443441 - FGÚ 2016 RIV NL eng J - Journal Article
Masoodi, M. - Kuda, Ondřej - Rossmeisl, Martin - Flachs, Pavel - Kopecký, Jan
Lipid signaling in adipose tissue: Connecting inflammation & metabolism.
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. Roč. 1851, č. 4 (2015), s. 503-518. ISSN 1388-1981. E-ISSN 1879-2618
R&D Projects: GA ČR(CZ) GA13-00871S; GA MŠMT(CZ) 7E12073; GA MŠMT(CZ) LH14040
Institutional support: RVO:67985823
Keywords : adipocyte * futile substrate cycle * macrophage
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 4.779, year: 2015

Accumulation of immune cells, especially macrophages, and macrophage polarization from M2 to M1 state, affect intrinsic WAT signaling, namely anti-inflammatory and proinflammatory cytokines, fatty acids (FA), and lipid mediators derived from both n−6 and n−3 long-chain PUFA. Studies in mice suggest that (i) transient accumulation of M2 macrophages could be essential for the control of tissue FA levels during activation of lipolysis, (ii) currently unidentified M2 macrophage-borne signaling molecule(s) could inhibit lipolysis and re-esterification of lipolyzed FA back to triacylglycerols (TAG/FA cycle), and (iii) the egress of M2 macrophages from rebuilt WAT and removal of the negative feedback regulation could allow for a full unmasking of metabolic activities of adipocytes. Thus, M2 macrophages could support remodeling of WAT to a tissue containing metabolically flexible adipocytes endowed with a high capacity of both TAG/FA cycling and oxidative phosphorylation. This situation could be exemplified by a combined intervention using mild calorie restriction and dietary supplementation with EPA/DHA, which enhances the formation of “healthy” adipocytes
Permanent Link: http://hdl.handle.net/11104/0246159