Effect of altered innervation and thyroid hormones on myosin heavy chain expression and fiber type transitions: a mini-review

0443170 - FGÚ 2016 RIV DE eng J - Journal Article
Soukup, Tomáš - Smerdu, V.
Effect of altered innervation and thyroid hormones on myosin heavy chain expression and fiber type transitions: a mini-review.
Histochemistry and Cell Biology. Roč. 143, č. 2 (2015), s. 123-130. ISSN 0948-6143. E-ISSN 1432-119X
R&D Projects: GA MŠMT(CZ) LH12058; GA MŠMT(CZ) 7AMB14SK123
Grant - others:EC(XE) LSH-CT-2004-511978
Institutional support: RVO:67985823
Keywords : muscle fiber types * muscle regeneration * muscle transplantation * MyHC isoforms * thyroid hormone status * innervation
Subject RIV: EA - Cell Biology
Impact factor: 2.780, year: 2015

We described data regarding the effect of extrinsic factors, i.e. innervation and thyroid hormones (TH) on myosin heavy chain (MyHC) genes and on isoforms expression and consequently on muscle fiber type transitions. It has been well known, that reduced neuromuscular activity, hyperthyroidism or mechanical unloading stimulate slow to fast fiber type transitions, while increased neuromuscular activity, hypothyroidism and higher mechanical loading result in fast to slow fiber type transitions. As there is a plethora of results on these topics, we focused on data relevant to our experimental model of slow to fast muscle transformation following heterochronous intramuscular isotransplantation in rats with altered TH status
Permanent Link: http://hdl.handle.net/11104/0245913