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Structure-dependent NO-, PGE2- and cytokine-inhibitory effects of pyrimidine derivatives
- 1.0442265 - ÚEM 2015 HR eng C - Conference Paper (international conference)
Zídek, Zdeněk - Kmoníčková, Eva - Janeba, Zlatko - Kolman, Viktor - Jansa, Petr
Structure-dependent NO-, PGE2- and cytokine-inhibitory effects of pyrimidine derivatives.
Proceedings of the Joint Meeting of the 8th International Symposium Nitric Oxide. organizátor symposia, 2014, s. 6-10. ISBN 978-80-971699-0-9.
[Proceedings of the Joint Meeting of the 8th International Symposium Nitric Oxide: From Basic Regulations to Lifestyle-Related Diseases and The 2nd Genetic and Environmental Factors in Hypertension [0312302]. Vrsan (HR), 15.09.2014-19.09.2014]
R&D Projects: GA ČR(CZ) GAP303/12/0172
Institutional support: RVO:68378041 ; RVO:61388963
Keywords : PGE2 * TNF-a * pyrimidine derivatives
Subject RIV: FR - Pharmacology ; Medidal Chemistry
We synthesized novel series of pyrimidine derivatives. Besides NO, the pyrimidine derivatives suppressed, though less effectively, the production of PGE2 and TNF-a. The data on mouse peritoneal cells suggest that the immunosuppressive properties of pyrimidines depend mainly on the presence of the 4,6-dichloropyrimidine scaffold.
Permanent Link: http://hdl.handle.net/11104/0245104
Number of the records: 1