Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies

0441648 - ÚŽFG 2015 RIV GB eng J - Journal Article
Žižková, Martina - Suchá, Rita - Tylečková, Jiřina - Jarkovská, Karla - Mairychová, Kateřina - Kotrčová, Eva - Marsala, M. - Gadher, S. J. - Kovářová, Hana
Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies.
Expert Review of Proteomics. Roč. 12, č. 1 (2015), s. 83-95. ISSN 1478-9450. E-ISSN 1744-8387
R&D Projects: GA MŠMT ED2.1.00/03.0124; GA TA ČR(CZ) TA01011466
Institutional support: RVO:67985904
Keywords : cell therapy * immunomodulation * neural stem cell differentiation * neural subpopulation * neurodegenerative disease
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.465, year: 2015

Neurodegenerative diseases are devastating disorders and the demands on their treatment are set to rise in connection with higher disease incidence. Knowledge of the spatiotemporal profile of cellular protein expression during neural differentiation and definition of a set of markers highly specific for targeted neural populations is a key challenge. Intracellular proteins may be utilized as a readout for follow-up transplantation and cell surface proteins may facilitate isolation of the cell subpopulations, while secreted proteins could help unravel intercellular communication and immunomodulation. This review summarizes the potential of proteomics in revealing molecular mechanisms underlying neural differentiation of stem cells and presents novel candidate proteins of neural subpopulations, where understanding of their functionality may accelerate transition to cell replacement therapies.
Permanent Link: http://hdl.handle.net/11104/0244650