Novel thermo-responsive double-hydrophilic and hydrophobic MPEO-b-PEtOx-b-PCL triblock terpolymers: synthesis, characterization and self-assembly studies

0440990 - ÚMCH 2015 RIV GB eng J - Journal Article
Petrova, Svetlana - Venturini, Cristina Garcia - Jäger, Alessandro - Jäger, Eliezer - Černoch, Peter - Kereiche, S. - Kováčik, L. - Raška, I. - Štěpánek, Petr
Novel thermo-responsive double-hydrophilic and hydrophobic MPEO-b-PEtOx-b-PCL triblock terpolymers: synthesis, characterization and self-assembly studies.
Polymer. Roč. 59, 24 February (2015), s. 215-225. ISSN 0032-3861. E-ISSN 1873-2291
R&D Projects: GA ČR GAP208/10/1600; GA MŠMT(CZ) 7F14009
Institutional support: RVO:61389013
Keywords : MPEO-b-PEtOx-b-PCL triblock terpolymers * light-scattering * thermo-responsive nanoparticles
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 3.586, year: 2015

A series of new double-hydrophilic and hydrophobic biocompatible ABC triblock terpolymers with different molecular weights of the PCL block (herein referred to as MPEO44-b-PEtOx263-b-PCL87, MPEO44-b-PEtOx263-b-PCL175, MPEO44-b-PEtOx263-b-PCL262) were successfully synthesized by a three-step pathway using a combination of living cationic and anionic ring-opening polymerization (ROP). First, α-methoxy-ω-hydroxy-poly(ethylene oxide) (MPEO) was end-capped with p-toluenesulfonyl chloride. ω-Tosyl-MPEO was used in the second step as a macroinitiator for the ROP of 2-ethyl-2-oxazoline (EtOx) to form the diblock copolymer, MPEO-b-PEtOx. Finally, the prepared diblock copolymer was used as a macroinitiator for the design of the PCL block by ROP of ε-caprolactone (ε-CL). Properties of the newly obtained compounds (macroinitiator, AB diblock and ABC triblock terpolymers) were assessed by 1H NMR and FT-IR spectroscopy and SEC analysis. The selected MPEO44-b-PEtOx263-b-PCL87 triblock terpolymers self-assembled under buffer-simulated physiological conditions into nanoparticles, which were fully characterized by static and dynamic light scattering, nanoparticle tracking analysis and cryo-transmission electron microscopy (cryo-TEM). The combination of the scattering methods revealed a temperature-induced aggregation driven by hydrogen bonding with the LCST approximately between 56 and 60 °C.
Permanent Link: http://hdl.handle.net/11104/0244148