0439756 - ÚEM 2015 RIV GB eng J - Journal Article
Burnstock, G. - Verkhratsky, Alexei
Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.
Cell Death & Disease. Roč. 1, č. 1 (2010), e9. ISSN 2041-4889. E-ISSN 2041-4889
Institutional support: RVO:68378041
Keywords : bone * cancer * epithelia
Subject RIV: FH - Neurology
Impact factor: 0.000, year: 2010

The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication. The ATP and its derivatives function as a danger signal in the most primitive forms of life. Purinoceptors are extraordinarily widely distributed in all cell types and tissues and they are involved in the regulation of an even more extraordinary number of biological processes. In addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion, there is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body. In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer.
Permanent Link: http://hdl.handle.net/11104/0242958