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Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-epsilon-caprolactone nanofibers and growth factors for prevention of incisional hernia formation
- 1.0439596 - FGÚ 2015 RIV NZ eng J - Journal Article
Plencner, M. - East, B. - Tonar, Z. - Otáhal, M. - Prosecká, E. - Rampichová, M. - Krejčí, T. - Litvinec, Andrej - Buzgo, M. - Míčková, A. - Nečas, A. - Hoch, J. - Amler, E.
Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-epsilon-caprolactone nanofibers and growth factors for prevention of incisional hernia formation.
International Journal of Nanomedicine. Roč. 9, č. 2014 (2014), s. 3263-3227. E-ISSN 1178-2013
Institutional support: RVO:67985823
Keywords : nanofibers * growth factors * surgical mesh
Subject RIV: FP - Other Medical Disciplines
Impact factor: 4.383, year: 2014
Incisional hernia affects up to 20% of patients after abdominal surgery. Currently used hernia repair meshes do not guarantee success but only extend the recurrence-free period by about 5 years. Electrospun nanofibers of various polymers have been used as tissue scaffolds, due to their low cost and good biocompatibility. We have tested a biodegradable polyester poly-e-caprolactone in the form of nanofibers as a scaffold for fascia healing in an abdominal closure reinforcement model for prevention of incisional hernia formation. Both in vitro tests and an experiment on a rabbit model have shown promising results
Permanent Link: http://hdl.handle.net/11104/0242839
Number of the records: 1