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Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems
- 1.0439486 - ÚMCH 2015 RIV GB eng J - Journal Article
Sedláček, Ondřej - Kučka, Jan - Hrubý, Martin
Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems.
Applied Radiation and Isotopes. Roč. 95, January (2015), s. 129-134. ISSN 0969-8043
R&D Projects: GA MPO FR-TI4/625; GA ČR GAP304/12/0950; GA MŠMT(CZ) LH14079
Grant - others:AV ČR(CZ) M200501201
Program: M
Institutional support: RVO:61389013
Keywords : doxorubicin * hydrazone * polymer conjugate
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 1.136, year: 2015
Hydrazone conjugates of polymers with doxorubicin represent a very promising tool for cancer chemotherapy. However, these conjugates are very difficult to radiolabel with iodine radionuclides, which possess otherwise very advantageous nuclear properties to, e.g., follow biodistribution. In this study, we developed a robust protocol for the high-yield radioiodination of hydrazone-type drug delivery systems with doxorubicin. In particular, it is crucial that the polymer radioiodination step be performed before the deprotection of the hydrazide and doxorubicin binding.
Permanent Link: http://hdl.handle.net/11104/0243451
Number of the records: 1