Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours

0438606 - ÚMCH 2015 RIV eng P - Patent Document
Etrych, Tomáš - Chytil, Petr - Strohalm, Jiří - Ulbrich, Karel - Říhová, Blanka
Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours.
2014. Owner: Ústav makromolekulární chemie AV ČR, v. v. i. - Mikrobiologický ústav AV ČR, v. v. i. Date of the patent acceptance: 26.02.2014. Patent Number: EP2512521
R&D Projects: GA AV ČR IAA400500806; GA AV ČR KAN200200651
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Keywords : polymer conjugates * doxorubicin * drug targeting
Subject RIV: CD - Macromolecular Chemistry
http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20140226&DB=EPODOC&locale=en_EP&CC=EP&NR=2512521B1&KC=B1&ND=4

The present invention relates to water-soluble high-molecular polymeric carriers of medicaments and their conjugates with medicaments, derived from dendrimers based on poly (amidoamine) and 2,2-bis(hydroxymethyl)propionic dendrimer, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through the mediation of biodegradable spacers. The polymer carriers and conjugates of the present invention enable targeted transport notably of anticancer medicaments into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The efficiency of the polymer carrier conjugated with a cancerostatic is directed to targeted therapy of human tumors.
Permanent Link: http://hdl.handle.net/11104/0242089