Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium

0438519 - ÚEM 2016 RIV US eng J - Journal Article
Blackburn, J. - Kawasaki, K. - Porntaveetus, T. - Kawasaki, M. - Otsuka-Tanaka, Y. - Miake, Y. - Ota, M. S. - Watanabe, M. - Hishinuma, M. - Nomoto, T. - Oommen, S. - Ghafoor, S. - Harada, F. - Nozawa-Inoue, K. - Maeda, T. - Peterková, Renata - Lesot, H. - Inoue, J. - Akiyama, T. - Schmidt-Ulrich, R. - Liu, B. - Hu, Y. - Page, A. - Ramírez, Á. - Sharpe, P. T. - Ohazama, A.
Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium.
Journal of Dental Research. Roč. 94, č. 1 (2015), s. 121-128. ISSN 0022-0345. E-ISSN 1544-0591
R&D Projects: GA ČR GB14-37368G
Institutional support: RVO:68378041
Keywords : incisor * tooth development
Subject RIV: EA - Cell Biology
Impact factor: 4.602, year: 2015

Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
Permanent Link: http://hdl.handle.net/11104/0241890