Direct C-H amination and C-H chloroamination of 7-deazapurines

0438287 - ÚOCHB 2015 RIV GB eng J - Journal Article
Sabat, Nazarii - Klečka, Martin - Slavětínská, Lenka - Klepetářová, Blanka - Hocek, Michal
Direct C-H amination and C-H chloroamination of 7-deazapurines.
RSC Advances. Roč. 4, č. 107 (2014), s. 62140-62143. E-ISSN 2046-2069
Grant - others:GA ČR(CZ) GAP207/12/0205
Institutional support: RVO:61388963
Keywords : catalyzed direct amination * cross-coupling reactions * 7-deazapurines
Subject RIV: CC - Organic Chemistry
Impact factor: 3.840, year: 2014

Protocols for selective Pd-Cu-catalyzed direct C-H amination or C-H chloroamination of 7-deazapurines with N-chloro-N-alkyl-arylsulfonamides have been developed leading either to 8-(arylsulfonyl)methylamino-7-deazapurines or to 7-chloro-8-(arylsulfonyl)methylamino-7-deazapurines. The scope and limitations of the methods, as well as synthesis of a small series of 6,8,9-tri- and 6,7,8,9-tetrasubstituted 7-deazapurines and deprotection of the sulfonamide are presented.
Permanent Link: http://hdl.handle.net/11104/0241839