Activation of respiratory complex II by interferongamma and its inhibition by pyrimidine derivatives

0437836 - ÚEM 2016 RIV SE eng J - Journal Article
Zídek, Zdeněk - Jansa, Petr - Kmoníčková, Eva
Activation of respiratory complex II by interferongamma and its inhibition by pyrimidine derivatives.
Neuroendocrinology Letters. Roč. 35, Supplement 2 (2014), s. 141-148. ISSN 0172-780X. E-ISSN 2354-4716
R&D Projects: GA ČR(CZ) GAP303/12/0172
Institutional support: RVO:68378041 ; RVO:61388963
Keywords : respiratory complex II * WST-1 assay * LDH assay
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 0.799, year: 2014

Mitochondrial respiration as measured by the activity of succinate dehydrogenase (respiratory complex II) was found to be augmented by interferon (IFN)-gamma in mouse peritoneal cells. The in vitro enhancing effect was inhibited by polysubstituted pyrimidine derivatives. It was suggested that pyrimidines interfere with IFN-gamma signaling pathways, notably with the expression of signal transducer and activator of transcription 3 (STAT3).
Permanent Link: http://hdl.handle.net/11104/0241357