A mathematical model of rat ventricular cardiomyocyte with a novel description of intracellular and t-tubular Ca2+ dynamics

0437440 - ÚT 2015 RIV CZ eng J - Journal Article
Pásek, Michal - Šimurda, J.
A mathematical model of rat ventricular cardiomyocyte with a novel description of intracellular and t-tubular Ca2+ dynamics.
Engineering Mechanics. Roč. 20, č. 6 (2013), s. 471-480. ISSN 1802-1484
Institutional support: RVO:61388998
Keywords : rat ventricular cardiomyocyte * t-tubules * rat ventricular cell model
Subject RIV: BO - Biophysics

In this paper, we present a novel quantitative description of intracellular and t-tubular Ca2+ dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular and peripheral L-type calcium current (ICa) and a description of exogenous Ca2+ buffer function in the intracellular space. The model is used to explore activity-induced changes of ion concentrations in the intracellular and t-tubular spaces and their role in excitation – contraction coupling in ventricular myocytes.
Permanent Link: http://hdl.handle.net/11104/0241748