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Formation of Cell-To-Cell Connection between Bone Marrow Cells and Isolated Rat Cardiomyocytes in a Cocultivation Model
- 1.0437439 - ÚT 2015 RIV US eng J - Journal Article
Skopalík, J. - Pásek, Michal - Rychtárik, M. - Koristek, Z. - Gabrielová, E. - Sheer, P. - Matejovič, P. - Modrianský, M. - Klabusay, M.
Formation of Cell-To-Cell Connection between Bone Marrow Cells and Isolated Rat Cardiomyocytes in a Cocultivation Model.
Journal of Cell Science and Therapy. Roč. 5, č. 5 (2014), s. 1000185. ISSN 2157-7013
Institutional support: RVO:61388998
Keywords : bone marrow * mononuclear cells * isolated cardiomyocytes * cocultivation
Subject RIV: BO - Biophysics
http://omicsonline.org/open-access/formation-of-celltocell-connection-between-bone-marrow-cells-and-isolated-rat-cardiomyocytes-2157-7013.1000185.php?aid=33364
Limited regenerative potential of cardiomyocytes (CMs) causes irreversible changes in heart tissue during pathological processes. However bone marrow mononuclear cells (BM-MNCs) can migrate to this tissue, incorporate to the area of dead or missing myocytes, and improve the global heart function. The mechanism of BMMSCs’ incorporation and interaction with CMs is not clear. Our aim was to create an in vitro model which would enable to study the interaction of BM-MNCs with CMs and to make a microscopy description of these interactions.
Permanent Link: http://hdl.handle.net/11104/0241385
Number of the records: 1