The first experiencies with new exposure system for the whole body inhalation experiments with small animals

0437350 - ÚIACH 2015 CZ eng C - Conference Paper (international conference)
Večeřa, Zbyněk - Mikuška, Pavel - Moravec, Pavel - Smolík, Jiří
The first experiencies with new exposure system for the whole body inhalation experiments with small animals.
NANOCON 2012, Conference Proceedings. Ostrava: Tanger, Ltd, 2013, s. 697-699. ISBN 978-80-87294-35-2.
[NANOCON 2012. Mezinárodní konference /4./. Brno (CZ), 23.10.2012-25.10.2012]
R&D Projects: GA ČR(CZ) GAP503/11/2315; GA ČR(CZ) GBP503/12/G147
Institutional support: RVO:68081715 ; RVO:67985858
Keywords : inhalation chamber * nanoparticles * small animals
Subject RIV: CB - Analytical Chemistry, Separation

The first experiences with an inhalation chamber constructed for long-term exposure studies of small animals to nanoparticles under strictly controlled experimental conditions. The inhalation chamber was build from a glass and stainless steel and allows possible long-term inhalation procedures with up to four discrete groups of mice or of rats population under controlled illumination, temperature, relative humidity and pressure. Doses up to 1 x 10(6) particles/cm(3) and size (10-60 nm) of nano-sized particles were synthesized via aerosol route in a hot wall tube flow reactor using thermal decomposition of metal organic precursors. The function of exposure system for whole body inhalation experiments was studied under real conditions in period from May to September 2012. No animals were used within this trial experiment.
Permanent Link: http://hdl.handle.net/11104/0240947