Advances in Biology and Medicine

0436764 - ÚEM 2015 US eng M - Monography Chapter
Hejčl, Aleš - Jendelová, Pavla - Syková, Eva
Adult Bone Marrow Stem Cells and Biocompatible Polymers in SCI Repair.
Advances in Biology and Medicine. New York: NOVA SCIENCE PUBLISHERS, 2010 - (Berhardt, L.), s. 199-222. ISBN 978-1-60876-863-9
Institutional support: RVO:68378041
Keywords : spinal cord injury * central nervous system * stromal cells
Subject RIV: FH - Neurology

The effects of implanted rat MSCs was compared with the implantation of a freshly prepared mononuclear fraction of bone marrow cells (BMCs) or the injection of granulocyte colony-stimulating factor. Lesioned animals grafted with MSCs, BMCs or treated with G-CSF had significantly smaller lesions and better motor performance. The transplantation of MSCs in animal models of chronic SCI (which result in cavity formation) led to only modest improvement. Autologous BMC implantation was used in a Phase I/II clinical trial in patients with SCI. Intra-arterial vs. intravenous administration and groups of acute vs. chronic patients were compared. Implantation was safe; in addition, 5 out of 6 patients with a subacute cervical lesion improved their function following the administration of BMCs via a. vertebralis.
Permanent Link: http://hdl.handle.net/11104/0240442