Antihistamine response: a dynamically refined function at the host-tick interface

0436594 - BC 2015 RIV GB eng J - Journal Article
Valdés, James J.
Antihistamine response: a dynamically refined function at the host-tick interface.
Parasites & Vectors. Roč. 7, OCT 31 2014 (2014), s. 491. ISSN 1756-3305. E-ISSN 1756-3305
R&D Projects: GA MŠMT(CZ) EE2.3.30.0032
Institutional support: RVO:60077344
Keywords : dynamics * histamine * lipocalin * competitive binding * tick saliva * ticks
Subject RIV: EC - Immunology
Impact factor: 3.430, year: 2014

Ticks counteract host inflammatory responses by secreting proteins from their saliva that compete for histamine binding. Among these tick salivary proteins are lipocalins, antiparallel beta-barrel proteins that sequester small molecules. A tick salivary lipocalin has been structurally resolved and experimentally shown to efficiently compete for histamine with its native receptor (e.g., H1 histamine receptor). To date, molecular dynamics simulations focus on protein-protein and protein-ligand interactions, but there are currently no studies for simultaneous ligand exploration between two competing proteins.
Permanent Link: http://hdl.handle.net/11104/0242705