Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status

0436413 - FGÚ 2015 RIV DE eng J - Journal Article
Kopecká, Kateřina - Zachařová, Gisela - Smerdu, V. - Soukup, Tomáš
Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status.
Histochemistry and Cell Biology. Roč. 142, č. 6 (2014), s. 677-684. ISSN 0948-6143. E-ISSN 1432-119X
R&D Projects: GA ČR(CZ) GA304/08/0256; GA MŠMT(CZ) LH12058; GA MŠMT(CZ) 7AMB14SK123
Grant - others:EC(XE) LSH-CT-2004-511978
Institutional support: RVO:67985823
Keywords : muscle fiber types * muscle regeneration * muscle transplantation * MyHC isoforms * thyroid hormone status
Subject RIV: EA - Cell Biology
Impact factor: 3.054, year: 2014

We studied the effect of regeneration, altered innervation and thyroid hormone levels on fiber type transitions in slow soleus (SOL) muscles grafted (GRAFT) into host extensor digitorum longus (EDLh) muscles of euthyroid (EU), hyperthyroid (HT) and hypothyroid (HY) Lewis strain rats. SOL muscles were excised from 3- to 4-week-old inbred Lewis rats and intramuscularly transplanted into EDLh muscles of 2-month-old female rats of the same strain. The transition towards fast muscle phenotype was more pronounced in HT status, where the fastest type 2B fibers predominated. On the contrary, in HY status, the slow to fast transformation was less pronounced, as GRAFT contained less type 2B and 2X but more type 2A and 1 fibers. We conclude that the type of innervation is the crucial factor for the slow to fast fiber type transitions in GRAFT, but the extent of muscle transformation is further modulated by altered TH status
Permanent Link: http://hdl.handle.net/11104/0240274