PAG - a multipurpose transmembrane adaptor protein

0435790 - ÚMG 2015 RIV GB eng J - Journal Article
Hrdinka, Matouš - Hořejší, Václav
PAG - a multipurpose transmembrane adaptor protein.
Oncogene. Roč. 33, č. 41 (2014), s. 4881-4892. ISSN 0950-9232. E-ISSN 1476-5594
R&D Projects: GA ČR(CZ) GBP302/12/G101
Institutional support: RVO:68378050
Keywords : PAG * adaptor protein * membrane raft
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.459, year: 2014

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways. It helps recruit cytoplasmic C-terminal Src kinase (Csk) to lipid raft-associated Src kinases, mediates a link to actin cytoskeleton and interacts with several other important cytoplasmic and plasma membrane-associated proteins. In recent years, PAG has been implicated in various aspects of cancer cell biology. Our review covers all so far published data on this interesting protein.
Permanent Link: http://hdl.handle.net/11104/0239663