TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

0435671 - FGÚ 2015 RIV GB eng J - Journal Article
Uchytilová, Eva - Špicarová, Diana - Paleček, Jiří
TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms.
Molecular Pain. Roč. 10, č. 2014 (2014), s. 67. E-ISSN 1744-8069
R&D Projects: GA MŠMT(CZ) EE2.3.30.0025; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) LH12058; GA ČR(CZ) GPP303/12/P510
Institutional support: RVO:67985823
Keywords : SB366791 * TRPV1 * allodynia * hyperalgesia * surgical pain * spinal cord
Subject RIV: FH - Neurology
Impact factor: 3.654, year: 2014

Acute postoperative pain is one of the frequent reasons for pain treatment. However, the exact mechanisms of its development are still not completely clear. Transient receptor potential vanilloid 1 (TRPV1) receptors are involved in nociceptive signaling in various hypersensitive states. Here we have investigated the contribution of TRPV1 receptors expressed on cutaneous peripheral nociceptive fibers and in the spinal cord on the development and maintenance of hypersensitivity to thermal and mechanical stimuli following surgical incision. A rat plantar incision model was used to test paw withdrawal responses to thermal and mechanical stimuli. The effect of the TRPV1 receptor antagonist SB366791 was investigated 1) by intrathecal injection 15 min before incision and 2) intradermal injection before (30 min) and immediately after the surgery. Vehicle-injected rats and naïve animals treated identically were used as controls
Permanent Link: http://hdl.handle.net/11104/0239624