Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

0435406 - BFÚ 2015 RIV GB eng J - Journal Article
Kolářová, Hana - Ambrůzová, Barbora - Šindlerová, Lenka - Klinke, A. - Kubala, Lukáš
Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions.
Mediators of Inflammation. Roč. 2014, April (2014). ISSN 0962-9351. E-ISSN 1466-1861
R&D Projects: GA ČR(CZ) GCP305/12/J038; GA MŠMT(CZ) ED1.100/02/0123
Institutional support: RVO:68081707
Keywords : HEPARAN-SULFATE PROTEOGLYCANS * ISCHEMIA-REPERFUSION INJURY * CAROTID-ARTERY BIFURCATION
Subject RIV: BO - Biophysics
Impact factor: 3.236, year: 2014

The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination.
Permanent Link: http://hdl.handle.net/11104/0239297