Glycogen-graft-poly(2-alkyl-2-oxazolines) - the new versatile biopolymer-based thermoresponsive macromolecular toolbox

0435100 - ÚMCH 2015 RIV GB eng J - Journal Article
Pospíšilová, Aneta - Filippov, Sergey K. - Bogomolova, Anna - Turner, S. - Sedláček, Ondřej - Matushkin, Nikolai - Černochová, Zulfiya - Štěpánek, Petr - Hrubý, Martin
Glycogen-graft-poly(2-alkyl-2-oxazolines) - the new versatile biopolymer-based thermoresponsive macromolecular toolbox.
RSC Advances. Roč. 4, č. 106 (2014), s. 61580-61588. E-ISSN 2046-2069
R&D Projects: GA ČR GA13-08336S; GA MŠMT(CZ) LH14079
Grant - others:AV ČR(CZ) M200501201; AV ČR(CZ) ASCR/CONICET 2012CZ006
Program: M
Institutional support: RVO:61389013
Keywords : glycogen * poly(2-alkyl-2-oxazoline) * hybrid copolymer
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 3.840, year: 2014

This study is focused on thermoresponsive glycogen-graft-poly(2-alkyl-2-oxazolines), a new group of nanostructured hybrid dendrimeric stimuli-responsive polymers connecting the body’s own biodegradable polysaccharidic dendrimer glycogen with the widely tuneable thermoresponsive behavior of polypeptide-analogic poly(2-alkyl-2-oxazolines), which are known to be biocompatible. Glycogen-graft-poly(2-alkyl-2-oxazolines) were prepared by a simple one-pot two-step procedure involving cationic ring-opening polymerization of 2-alkyl-2-oxazolines followed by termination of the living cationic ends with sodium glycogenate. As confirmed by light and X-ray scattering, as well as cryo-transmission electron microscopy, the grafted dendrimer structure allows easy adjustment of the cloud point temperature, the concentration dependence and nanostructure of the self-assembled phase separated polymer by crosstalk during graft composition, the graft length and the grafting density, in a very wide range.
Permanent Link: http://hdl.handle.net/11104/0240962