Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

0434359 - ÚACH 2015 RIV CH eng J - Journal Article
Vaculíková, E. - Grünwaldová, Veronika - Král, V. - Dohnal, J. - Jampílek, J.
Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation.
Molecules. Roč. 17, č. 11 (2012), s. 13221-13234. E-ISSN 1420-3049
Institutional support: RVO:61388980
Keywords : candesartan cilexetil * atorvastatin * nanoparticles * solvent evaporation * excipients * dynamic light scattering
Subject RIV: CA - Inorganic Chemistry
Impact factor: 2.428, year: 2012

The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging to class II of the biopharmaceutical classification system, were chosen as model active pharmaceutical ingredients in this study. Forty samples were prepared either by antisolvent precipitation/solvent evaporation method or by the emulsion/solvent evaporation technique with various commonly used surface-active excipients as nanoparticle stabilizers. All samples were analyzed by means of dynamic light scattering. The particle size of the determined 36 nanoparticle samples was to 574 nm, whereas 32 samples contained nanoparticles of less than 200 nm. Relationships between solvents and excipients used and their amount are discussed. Based on the results the investigated solvent evaporation methods can be used as an effective and an affordable technique for the preparation of nanoparticles.
Permanent Link: http://hdl.handle.net/11104/0238447