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Renaissance of mammalian endogenous RNAi
- 1.0434358 - ÚMG 2015 RIV NL eng J - Journal Article
Svoboda, Petr
Renaissance of mammalian endogenous RNAi.
FEBS Letters. Roč. 588, č. 15 (2014), 2550–2556. ISSN 0014-5793. E-ISSN 1873-3468
R&D Projects: GA MŠMT LH13084; GA ČR GA13-29531S
Institutional support: RVO:68378050
Keywords : RNAi * Dicer * Oocyte * Virus * Retrotransposon
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.169, year: 2014
RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA). RNAi is an ancient eukaryotic defense mechanism against viruses and mobile elements. In mammals, endogenous RNAi was outstripped during evolution by the current innate and acquired immunity. The RNAi apparatus, which remains essentially intact, serves mostly the microRNA pathway, which regulates endogenous gene expression. Remarkably, several recent publications brought the mammalian endogenous RNAi pathway back into the spotlight. Here, I will provide an up-to-date review of the mammalian endogenous RNAi pathway with a focus on its defensive role and overlaps with miRNA and piRNA pathways.
Permanent Link: http://hdl.handle.net/11104/0245523
Number of the records: 1