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Age and activation determines the anticonvulsant effect of ifenprodil in rats
- 1.0434262 - FGÚ 2015 RIV DE eng J - Journal Article
Mareš, Pavel
Age and activation determines the anticonvulsant effect of ifenprodil in rats.
Naunyn-Schmiedeberg's Archives of Pharmacology. Roč. 387, č. 8 (2014), s. 753-761. ISSN 0028-1298. E-ISSN 1432-1912
R&D Projects: GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:67985823
Keywords : NMDA receptors * NR2B subunit * anticonvulsant action * ontogeny * rat
Subject RIV: FH - Neurology
Impact factor: 2.471, year: 2014
Ifenprodil is an antagonist of MDA receptors containing NR2B subunit. This subunit is dominant at early stages of brain development and therefore the anticonvulsant effect of this drug is marked in very young rats
Permanent Link: http://hdl.handle.net/11104/0238354
Number of the records: 1