Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats

0433963 - ÚOCHB 2015 RIV GB eng J - Journal Article
Špolcová, Andrea - Mikulášková, Barbora - Kršková, K. - Gajdošechová, L. - Zórad, Š. - Olszanecki, R. - Suski, M. - Bujak-Gizycka, B. - Železná, Blanka - Maletínská, Lenka
Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats.
BMC Neuroscience. Roč. 15, Sep 25 (2014), 111/1-111/8. ISSN 1471-2202. E-ISSN 1471-2202
R&D Projects: GA ČR GAP303/12/0576; GA MŠMT 7AMB12FR011
Institutional support: RVO:61388963
Keywords : Zucker fa/fa rats * insulin resistance * obesity * GSK-3 beta * Tau protein
Subject RIV: CE - Biochemistry
Impact factor: 2.665, year: 2014

Background: Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resistance and aging are risk factors for central insulin resistance and whether central insulin resistance is related to the pathologic phosphorylation of the Tau protein. Results: Aging and obesity significantly attenuated the phosphorylation of the insulin cascade kinases Akt (protein kinase B, PKB) and GSK-3 beta (glycogen synthase kinase 3 beta) in the hippocampi of the fa/fa rats. Furthermore, the hyperphosphorylation of Tau Ser396 alone and both Tau Ser396 and Thr231 was significantly augmented by aging and obesity, respectively, in the hippocampi of these rats. Conclusions: Both age-induced and obesity-induced peripheral insulin resistance are associated with central insulin resistance that is linked to hyperTau phosphorylation. Peripheral hyperinsulinemia, rather than hyperglycemia, appears to promote central insulin resistance and the Tau pathology in fa/fa rats.
Permanent Link: http://hdl.handle.net/11104/0238384