In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb

0433742 - ÚEB 2015 RIV PK eng J - Journal Article
Landa, Přemysl - Skálová, L. - Boušová, I. - Kutil, Zsófia - Langhansová, Lenka - Lou, J.D. - Vaněk, Tomáš
In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.
Pakistan Journal of Pharmaceutical Sciences. Roč. 27, č. 1 (2014), s. 103-106. ISSN 1011-601X
R&D Projects: GA MŠMT ME08070
Institutional support: RVO:61389030
Keywords : anti-proliferative activity * anti-inflammatory activity * breast cancer
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 0.682, year: 2014
http://www.pjps.pk/wp-content/uploads/pdfs/27/1/Paper-15.pdf

The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 mug/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 mug/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.
Permanent Link: http://hdl.handle.net/11104/0237917