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Isoquercitrin: Pharmacology, toxicology, and metabolism
- 1.0433017 - MBÚ 2015 RIV GB eng J - Journal Article
Valentová, Kateřina - Vrba, J. - Bancířová, M. - Ulrichová, J. - Křen, Vladimír
Isoquercitrin: Pharmacology, toxicology, and metabolism.
Food and Chemical Toxicology. Roč. 68, JUN 2014 (2014), s. 267-282. ISSN 0278-6915. E-ISSN 1873-6351
R&D Projects: GA ČR GPP301/12/P381; GA MŠMT(CZ) LD13041; GA MŠMT(CZ) 7E11011; GA ČR(CZ) GAP301/11/0767
Grant - others:GA ČR(CZ) GAP303/12/G163
Program: GA
Institutional support: RVO:61388971
Keywords : Quercetin-3-glucoside * Quercetin-3-O-beta-D-glucopyranoside * Enzymatically modified isoquercitrin
Subject RIV: CE - Biochemistry
Impact factor: 2.895, year: 2014
The flavonoid isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and "enzymatically modified (alpha-glucosylated) isoquercitrin" (EMIQ). Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with alpha-L-rhamnosidase. Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver
Permanent Link: http://hdl.handle.net/11104/0237299
Number of the records: 1