Number of the records: 1  

Access to bifunctionalized biomolecular platforms using oxime ligation

  1. 1.
    0432688 - MBÚ 2015 RIV NL eng J - Journal Article
    Křenek, Karel - Gažák, Radek - Daskhan, G. Ch. - Garcia, J. - Fiore, M. - Dumy, P. - Šulc, Miroslav - Křen, Vladimír - Renaudet, O.
    Access to bifunctionalized biomolecular platforms using oxime ligation.
    Carbohydrate Research. Roč. 393, JUL 2014 (2014), s. 9-14. ISSN 0008-6215. E-ISSN 1873-426X
    R&D Projects: GA MŠMT(CZ) LD13042
    Institutional support: RVO:61388971
    Keywords : Chemoselective ligation * Glycocluster * Cyclopeptide
    Subject RIV: CC - Organic Chemistry
    Impact factor: 1.929, year: 2014

    This paper describes an efficient oxime ligation strategy to prepare multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepared. In one class, we attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an additional substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resolution mass spectrometry
    Permanent Link: http://hdl.handle.net/11104/0237066

     
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.