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Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
- 1.0432596 - ÚEM 2015 RIV IE eng J - Journal Article
Líbalová, Helena - Krčková, S. - Uhlířová, Kateřina - Milcová, Alena - Schmuczerová, Jana - Cigánek, M. - Kléma, J. - Machala, M. - Šrám, Radim - Topinka, Jan
Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants.
Toxicology Letters. Roč. 225, č. 3 (2014), s. 350-357. ISSN 0378-4274. E-ISSN 1879-3169
R&D Projects: GA ČR GAP503/11/0142
Institutional support: RVO:68378041
Keywords : air pollutin * DNA adducts * complex mixtures
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 3.262, year: 2014
We compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent transcriptional changes of selected target genes in human lung epithelial A549 cells incubated for 24 h, either with extractable organic matter (EOMs) from airborne particles <2.5 μm (PM2.5) Our results suggested inhibition of formation of B[a]P-induced DNA adducts compared to individual B[a]P, probably attributable to competitive inhibition by other non-genotoxic EOM components.
Permanent Link: http://hdl.handle.net/11104/0236980
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