Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

0431311 - FGÚ 2015 RIV US eng J - Journal Article
Pepino, M. Y. - Kuda, Ondřej - Samovski, D. - Abumrad, N. A.
Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism.
Annual Review of Nutrition. Roč. 34, JULY (2014), s. 281-303. ISSN 0199-9885. E-ISSN 1545-4312
R&D Projects: GA ČR(CZ) GP13-04449P
Institutional support: RVO:67985823
Keywords : fat taste * chylomicron * VLDL * CCK * secretin * calcium * FA binding * phospholipase * eicosanoid
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.359, year: 2014

CD36 is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids
Permanent Link: http://hdl.handle.net/11104/0235884