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Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice
- 1.0431306 - FGÚ 2015 RIV GB eng J - Journal Article
Teodoro, J.S. - Zouhar, Petr - Flachs, Pavel - Bardová, Kristina - Janovská, Petra - Gomes, A.P. - Duarte, F.V. - Varela, A.T. - Rolo, A.P. - Palmeira, C.M. - Kopecký, Jan
Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice.
International Journal of Obesity. Roč. 38, č. 8 (2014), s. 1027-1034. ISSN 0307-0565. E-ISSN 1476-5497
R&D Projects: GA MŠMT(CZ) 7E12073; GA ČR(CZ) GA13-00871S
Institutional support: RVO:67985823
Keywords : white adipose tissue * uncoupling protein 1 * energy expenditure * bile acids
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 5.004, year: 2014
In this study, the effects of natural bile acid, chenodeoxycholic acid (CDCA), on dietary obesity, UCP1 in both interscapular BAT and in white adipose tissue (brite cells in WAT), were characterized in dietary-obese mice. In the 8-week reversion, the CDCA intervention resulted in a dose-dependent reduction of obesity, dyslipidaemia and glucose intolerance, which could be largely explained by a transient decrease in food intake. The 3-week reversion revealed mild CDCA-dependent and food intake-independent induction of UCP1-mediated thermogenesis in interscapular BAT, negligible increase of UCP1 in subcutaneous WAT and a shift from carbohydrate to lipid oxidation
Permanent Link: http://hdl.handle.net/11104/0235883
Number of the records: 1