Determination of impurities and counterions of pharmaceuticals by capillary electromigration methods

0430911 - ÚOCHB 2015 RIV DE eng J - Journal Article
Štěpánová, Sille - Kašička, Václav
Determination of impurities and counterions of pharmaceuticals by capillary electromigration methods.
Journal of Separation Science. Roč. 37, č. 15 (2014), s. 2039-2055. ISSN 1615-9306. E-ISSN 1615-9314
R&D Projects: GA ČR(CZ) GAP206/12/0453; GA ČR(CZ) GA13-17224S
Institutional support: RVO:61388963
Keywords : pharmaceutical analysis * drug impurities * drug counterions * chiral impurities * capillary electrophoresis
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 2.737, year: 2014

The review presents a survey of recent applications of high-performance capillary electromigration methods-capillary zone electrophoresis, nonaqueous capillary electrophoresis, capillary isotachophoresis, micellar electrokinetic chromatography, microemulsion electrokinetic chromatography and capillary electrochromatography-for the determination of impurities of pharmaceuticals, including chiral impurities, for the period 2007-2013. In addition, due to the missing evaluation of the determination of counterions of pharmaceuticals by capillary electromigration methods in the last 20 years, the publications dealing with this topic since 1995 are included in this review. General aspects of both these types of applications of capillary electromigration methods in pharmaceutical analysis are discussed, and detailed experimental conditions used for determination of various chemical impurities and counterions of many particular drugs are described.
Permanent Link: http://hdl.handle.net/11104/0235583