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Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients
- 1.0430218 - ÚEM 2015 RIV GB eng J - Journal Article
Vymetálková, Veronika - Slyšková, Jana - Korenková, Vlasta - Bielik, Ludovít - Langerová, Lucie - Procházka, Pavel - Rejhová, Alexandra - Schwarzová, L. - Pardini, B. - Naccarati, Alessio - Vodička, Pavel
Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients.
BMC Medical Genetics. Roč. 15, č. 1 (2014), s. 17. E-ISSN 1471-2350
R&D Projects: GA AV ČR IAA500200917; GA ČR(CZ) GPP304/11/P715
Grant - others:GA MŠk(CZ) Prvouk-P27/LF1/1
Institutional support: RVO:68378041 ; RVO:86652036
Keywords : colorectal cancer * mismatch repair genes * expression levels
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.083, year: 2014
The present study aimed at characterizing of epigenetic and gene expression profiles of MMR genes in sporadic CRC patients from the Czech Republic, a country with one of the highest incidences of this cancer all over Europe. In our study, we have observed different pattern of MMR genes expression according to tumor localization. However, a lack of association between methylation in MMR genes and their corresponding expressions was noticed in this study, the relationship between these two aspects is worthy to be analyzed in larger population studies and in pre-malignant stages.
Permanent Link: http://hdl.handle.net/11104/0235127
Number of the records: 1