Determination of enantiopurity of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins-based chiral selectors

0430071 - ÚOCHB 2015 CZ eng C - Conference Paper (international conference)
Šolínová, Veronika - Kaiser, Martin Maxmilian - Lukáč, Miloš - Janeba, Zlatko - Kašička, Václav
Determination of enantiopurity of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins-based chiral selectors.
Acta Universitatis Palackianae Olomucensis. Facultas Rerum Naturalium. Chemica 51S. Olomouc: Palacký University, 2014 - (Maier, V.; Ševčík, J.), s. 207-209. ISBN 978-80-244-3950-1. ISSN 0232-0061.
[Advances in Chromatography and Electrophoresis & Chiranal 2014. Olomouc (CZ), 10.02.2014-14.02.2014]
R&D Projects: GA ČR(CZ) GAP206/12/0453; GA ČR(CZ) GA13-17224S; GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * capillary electrophoresis * enantiopurity analysis
Subject RIV: CB - Analytical Chemistry, Separation

Capillary electrophoresis with neutral and cationic cyclodextrins as chiral selectors was applied for determination of enantiopurity analysis of new types of six acyclic nucleoside phosphonates, nucleotide analogues bearing ((3-hydroxypropan-2-yl)-1H-1,2,3-triazol-4-yl)phosphonic acid, 2-((diisopropoxyphosphonyl)methoxy)propanoic acid or 2 (phosphonomethoxy)propanoic acid moieties attached to adenine, guanine, 2,6-diaminopurine, uracil and 5-bromouracil nucleobases. All these compounds were found to be synthesized in pure enantiomeric forms. Employing the UV-absorption detection at 206 nm, their detection limits were in the low micromolar level.
Permanent Link: http://hdl.handle.net/11104/0235088