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Mechanism of base excision with the hOGG1 DNA repair enzyme
- 1.0429733 - ÚOCHB 2015 RIV CZ eng J - Journal Article
Šebera, Jakub - Trantírek, L. - Fukal, J. - Tanaka, Y. - Sychrovský, Vladimír
Mechanism of base excision with the hOGG1 DNA repair enzyme.
Chemické listy. Roč. 108, č. 4 (2014), s. 364-367. ISSN 0009-2770. E-ISSN 1213-7103
R&D Projects: GA ČR GA13-27676S
Grant - others:CEITEC(XE) CZ.1.05/1.1.00/02.0068
Institutional support: RVO:61388963
Keywords : hOGG1 * base excision repair * theoretical modelling * N-pyramidalization
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 0.272, year: 2014
This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substrate-specific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.
Permanent Link: http://hdl.handle.net/11104/0234803
Number of the records: 1