Adaptation Biology and Medicine: New Challenges

0429322 - FGÚ 2015 RIV IN eng M - Monography Chapter
Radošinská, J. - Bačová, B. - Vinczenzová, C. - Beňová, T. - Knezl, V. - Žurmanová, J. - Soukup, Tomáš - Goncalvesová, E. - Slezák, J. - Tribulová, N.
Maladaptive Myocardial Responses to Hypertension are Attenuated by Omega-3 Fatty Acids and Red Palm Oil Intake.
Adaptation Biology and Medicine: New Challenges. Vol. 7. New Delhi: Narosa Publishing House, 2014 - (Popescu, L.; Hargens, A.; Singal, P.), s. 19-34. ISBN 978-81-8487-214-9
R&D Projects: GA ČR(CZ) GA304/08/0256; GA MŠMT(CZ) 7AMB12SK158
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : hypertension * arrhythmias * connexin and gap junctions * fibrillations
Subject RIV: EA - Cell Biology

Using immunohistochemistry, electron microscopy, western blotting and real time PCR, we have found that abnormal distribution and down-regulation of Cx43 accompanied with altered PKCε signaling in spontaneously hypertensive rats (SHR) were linked with increased propensity to ventricular fibrillation (VF) comparing to age-matched normotensive rats. On the other hand, attenuation of hypertension-related myocardial Cx43 abnormalities by treatment with omega-3 fatty acids or red palm oil confers protection from malignant arrhythmias in SHR
Permanent Link: http://hdl.handle.net/11104/0234446