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Natural variation of histone modification and its impact on gene expression in the rat genome
- 1.0429012 - FGÚ 2015 RIV US eng J - Journal Article
Rintisch, C. - Heinig, M. - Bauerfeind, A. - Schafer, S. - Mieth, Ch. - Patone, G. - Hummel, O. - Chen, W. - Cook, S. - Cuppen, E. - Colomé-Tatché, M. - Johannes, F. - Jansen, R. C. - Neil, H. - Werner, M. - Pravenec, Michal - Vingron, M. - Hubner, N.
Natural variation of histone modification and its impact on gene expression in the rat genome.
Genome Research. Roč. 24, JUN (2014), s. 942-953. ISSN 1088-9051. E-ISSN 1549-5469
R&D Projects: GA MŠMT(CZ) 7E10067; GA ČR(CZ) GAP301/10/0290; GA MŠMT(CZ) LL1204
Institutional support: RVO:67985823
Keywords : ChIP-seq * histone modification * gene expression * genetic linkage analysis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 14.630, year: 2014
Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. The integrated analysis of DNA variation together with histone methylation and gene expression levels showed that histone QTLs are an important predictor of gene expression and that a joint analysis significantly enhanced the prediction of gene expression traits (eQTLs). Our data suggest that genetic variation has widespread impact on histone trimethylation marks that may help to uncover novel genotype-phenotype relationships
Permanent Link: http://hdl.handle.net/11104/0234214
Number of the records: 1