Synthesis and biological properties of polysubstituted 5-nitrosopyrimidines

0429005 - ÚOCHB 2015 CZ eng C - Conference Paper (international conference)
Janeba, Zlatko - Čechová, Lucie - Žurek, Jiří - Procházková, Eliška - Dračínský, Martin
Synthesis and biological properties of polysubstituted 5-nitrosopyrimidines.
Chemistry of Nucleic Acid Components. 16th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 - (Hocek, M.), s. 285-286. Collection Symposium Series, 14. ISBN 978-80-86241-50-0.
[Symposium on Chemistry of Nucleic Acid Components /16./. Český Krumlov (CZ), 08.06.2014-13.06.2014]
R&D Projects: GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : polysubstituted 5-nitrosopyrimidines * intramolecular hydrogen bond * NMR spectroscopy
Subject RIV: CC - Organic Chemistry

2,4,6-Triamino-5-nitrosopyrimidines have been reported to contain a strong intramolecular hydrogen bond between the 5-nitroso and 4- or 6-amino groups, thus forming an additional pseudoring. Such analogues were speculated to be good mimics of fused bicyclic derivatives, e.g. purines. A series of novel polysubstituted 2-amino-5-nitrosopyrimidines, as potential structural mimics of modifi ed purine nucleos(t)ides well-known for their important biological properties, has been designed and synthesized. The physicochemical and biological properties of the prepared polysubstituted 2-amino-5-nitrosopyrimidines are being evaluated.
Permanent Link: http://hdl.handle.net/11104/0234286