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Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats
- 1.0428434 - FGÚ 2015 RIV GB eng J - Journal Article
Khuzakhmetova, V. - Samigullin, D. - Nurullin, L. - Vyskočil, František - Nikolsky, E. - Bukharaeva, E.
Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats.
International Journal of Developmental Neuroscience. Roč. 34, MAY (2014), s. 9-18. ISSN 0736-5748. E-ISSN 1873-474X
R&D Projects: GA AV ČR(CZ) IAA500110905
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : ryanodine receptor * synaptic latency
Subject RIV: ED - Physiology
Impact factor: 2.580, year: 2014
The kinetics of the phasic synchronous and delayed asynchronous release of acetylcholine quanta wasstudied at the neuromuscular junctions of aging rats from infant to mature animals at various frequen-cies of rhythmic stimulation of the motor nerve. We found that in infants 6 (P6) and 10 (P10) daysafter birth a strongly asynchronous phase of quantal release was observed, along with a reduced num-ber of quanta compared to the synapses of adults. Therefore, high degree of asynchrony of quantal release in infants is not associatedwith the activity of ryanodine receptors and with the liberation of calcium ions from intracellular calcium stores
Permanent Link: http://hdl.handle.net/11104/0233792
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