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Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamate treatment in the model of focal cerebral ischemia in immature rats
- 1.0428432 - FGÚ 2015 RIV IE eng J - Journal Article
Kletečková, Lenka - Tsenov, Grygoriy - Kubová, Hana - Stuchlík, Aleš - Valeš, Karel
Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamate treatment in the model of focal cerebral ischemia in immature rats.
Neuroscience Letters. Roč. 564, APR 3 (2014), s. 11-15. ISSN 0304-3940. E-ISSN 1872-7972
R&D Projects: GA ČR(CZ) GPP304/11/P386; GA ČR(CZ) GBP304/12/G069; GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA ČR(CZ) GA14-03627S
Grant - others:Univerzita Karlova(CZ) 604412
Institutional support: RVO:67985823
Keywords : 3 alpha 5 beta-Pregnanolone glutamate * NMDA receptor * immature rats * focal cerebral * ischemia * endothelin-1
Subject RIV: FH - Neurology
Impact factor: 2.030, year: 2014
3 alpha 5 beta-pregnanolone glutamate as a new therapeutic agent does not show direct neurotoxic effect in immature brain. Well-timed administration of 3 alpha 5 beta-pregnanolone glutamate significantly reduced range of neuronal damage in the endothelin-1 model of the focal cerebral ischemia in immature rats
Permanent Link: http://hdl.handle.net/11104/0233798
Number of the records: 1