Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension

0428198 - FGÚ 2015 RIV NL eng J - Journal Article
Sollinger, D. - Eissler, R. - Lorenz, S. - Strand, S. - Chmielewski, S. - Aoqui, C. - Schmaderer, Ch. - Bluyssen, H. - Zicha, Josef - Witzke, O. - Scherer, E. - Lutz, J. - Heemann, U. - Baumann, M.
Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension.
Cardiovascular Research. Roč. 101, č. 3 (2014), s. 464-472. ISSN 0008-6363. E-ISSN 1755-3245
R&D Projects: GA ČR(CZ) GA305/09/0336
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : innate immunity * Toll-like receptors * reactive oxygen species * vascular contractility
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 5.940, year: 2014

Hypertension is associated with end-organ damage and thus might lead to the release of damage-associated molecular patterns (DAMPs), which are endogenous activators of TLR4 receptors. The present study aimed to elucidate whether TLR4 signalling is able to modulate vascular contractility in an experimental model of hypertension thus contributing to blood pressure regulation. NG-nitro-l-arginine methyl ester (l-NAME)-induced hypertension was blunted in TLR4(-/-) when compared with wild-type mice. Cell damage-associated TLR4 signalling might act as a direct mediator of vascular contractility providing a molecular link between inflammation and hypertension
Permanent Link: http://hdl.handle.net/11104/0233594