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Antioxidant and regulatory role of mitochondrial uncoupling protein UCP2 in pancreatic beta-cells
- 1.0428036 - FGÚ 2015 RIV CZ eng J - Journal Article
Ježek, Petr - Olejár, Tomáš - Smolková, Katarína - Ježek, Jan - Dlasková, Andrea - Plecitá-Hlavatá, Lydie - Zelenka, Jaroslav - Špaček, Tomáš - Engstová, Hana - Reguera Pajuelo, David - Jabůrek, Martin
Antioxidant and regulatory role of mitochondrial uncoupling protein UCP2 in pancreatic beta-cells.
Physiological Research. Roč. 63, Suppl.1 (2014), S73-S91. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GAP302/10/0346; GA ČR(CZ) GAP305/12/1247; GA ČR(CZ) GPP304/10/P204; GA MŠMT(CZ) EE2.3.30.0025
Institutional support: RVO:67985823
Keywords : mitochondria * uncoupling protein UCP2 * pancreatic beta-cells * reactive oxygen species * glucose-stimulated insulin secretion
Subject RIV: EA - Cell Biology
Impact factor: 1.293, year: 2014
We review physiological roles of mitochondrial uncoupling protein UCP2 emphasising its roles in pancreatic beta-cells. We discuss the antioxidant roles of UCP2, its participation in redox regulations, and the regulation of glucose-stimulated insulin secretion. We also point out the role of phospholipase iPLA2gamma in the regulation of UCP2 antioxidant function
Permanent Link: http://hdl.handle.net/11104/0233445
Number of the records: 1