Effects of long-term thyroid hormone level alterations, n-3 polyunsaturated fatty acid supplementation and statin administration in rats

0428031 - FGÚ 2015 RIV CZ eng J - Journal Article
Soukup, Tomáš
Effects of long-term thyroid hormone level alterations, n-3 polyunsaturated fatty acid supplementation and statin administration in rats.
Physiological Research. Roč. 63, Suppl.1 (2014), S119-S131. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA304/08/0256; GA ČR(CZ) GA305/09/1228; GA ČR(CZ) GAP304/12/0259; GA MŠMT(CZ) LH12058; GA MŠMT(CZ) 7AMB12SK158; GA MŠMT(CZ) 7AMB14SK123
Grant - others:EC(XE) LSH-CT-2004-511978
Institutional support: RVO:67985823
Keywords : thyroid hormones * n-3 polyunsaturated fatty acids (n-3 PUFA) * statins * rat muscle proteins * cardiac remodeling
Subject RIV: ED - Physiology
Impact factor: 1.293, year: 2014

Thyroid hormones (THs) play multiple roles in the organism and alterations of their levels can result in many pathological changes. Currently, we use hyperthyroid and hypothyroid rats as “models of a diseased organism” and analyze whether n-3 polyunsaturated fatty acids (n-3 PUFA) administration can ameliorate TH-induced pathophysiological changes. As THs and n-3 PUFA possess multiple sites of potential action, we hope that our complex research will contribute to a better understanding of their actions, which can be useful in the treatment of different pathophysiological events including cardiac insufficiency in humans
Permanent Link: http://hdl.handle.net/11104/0233443