Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system

0427945 - FGÚ 2015 RIV CZ eng J - Journal Article
Zicha, Josef - Dobešová, Zdenka - Behuliak, Michal - Pintérová, Mária - Kuneš, Jaroslav - Vaněčková, Ivana
Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system.
Physiological Research. Roč. 63, č. 1 (2014), s. 13-26. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) 1M0510; GA ČR(CZ) GA305/09/0336; GA ČR(CZ) GAP304/12/0259
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : voltage-gated caclium channels * sympathetic nervous system * renin-angiotensin system * nitric oxide
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 1.293, year: 2014

High blood pressure (BP) of spontaneously hypertensive rats (SHR) is maintained by enhanced activity of sympathetic nervous system (SNS), whereas that of Ren-2 transgenic rats (Ren-2 TGR) by increased activity of renin-angiotensin system (RAS). However, both types of hypertension are effectively attenuated by chronic blockade of L-type voltage-dependent calcium channel (L-VDCC). The aim of our study was to evaluate whether the magnitude of BP response elicited by acute nifedipine administration is proportional to the alterations of particular vasoactive systems (SNS, RAS, NO) known to modulate L-VDCC activity. In conclusion, BP response to nifedipine is proportional to the vasoconstrictor activity exerted by both SNS and RAS, indicating a key importance of these two pressor systems for actual L-VDCC opening necessary for BP maintenance
Permanent Link: http://hdl.handle.net/11104/0233388