The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats

0427943 - FGÚ 2015 RIV CZ eng J - Journal Article
Zicha, Josef - Behuliak, Michal - Pintérová, Mária - Bencze, Michal - Kuneš, Jaroslav - Vaněčková, Ivana
The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats.
Physiological Research. Roč. 63, Suppl.1 (2014), S19-S27. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA305/09/0336; GA ČR(CZ) GAP304/12/0259
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : calcium sensitization * RhoA/Rho kinase * fasudil * calcium entry * nifedipine
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 1.293, year: 2014

The basal fasudil-sensitive calcium sensitization determined in rats deprived of endogenous renin-angiotensin system (RAS) and sympathetic nervous system (SNS) in which calcium entry was dose-dependently increased by L-VDCC opener BAY K8644, is smaller in spontaneously hypertensive rats (SHR) than in normotensive Wistar-Kyoto (WKY) rats. In contrast, if endogenous RAS and SNS were present in intact rats, fasudil caused a greater BP fall in SHR than WKY rats. Our in vivo experiments indicated that the endogenous pressor systems (RAS and SNS) augment calcium sensitization mediated by RhoA/Rho kinase pathway, whereas the endogenous vasodilator systems (such as nitric oxide) attenuate this pathway
Permanent Link: http://hdl.handle.net/11104/0233364