Chronic Hypoxia Enhances Expression and Activity of Mitochondrial Creatine Kinase and Hexokinase in the Rat Ventricular Myocardium

0427789 - FGÚ 2015 RIV CH eng J - Journal Article
Wasková-Arnoštová, P. - Kašparová, D. - Elsnicová, B. - Novotný, J. - Neckář, Jan - Kolář, František - Žurmanová, J.
Chronic Hypoxia Enhances Expression and Activity of Mitochondrial Creatine Kinase and Hexokinase in the Rat Ventricular Myocardium.
Cellular Physiology and Biochemistry. Roč. 33, č. 2 (2014), s. 310-320. ISSN 1015-8987
R&D Projects: GA AV ČR(CZ) IAAX01110901; GA ČR(CZ) GAP303/12/1162
Grant - others:Univerzita Karlova(CZ) 349211; GA AV ČR(CZ) IAA601110908
Institutional support: RVO:67985823
Keywords : creatine kinase * hexokinase * normobaric hypoxia * left ventricle * right ventricle * mitochondria co-localization
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 2.875, year: 2014

The expression and enzyme activity of creatine kinase (CK) and hexokinase (HK) in the left (LV) and right (RV) ventricles of rats adapted for 3 weeks to normobaric hypoxia (10 % O2) either continuously (CNH) or intermittently with 1-h or 16-h normoxic episode per day were analyzed. Our results shown that up-regulation of mitochondrial CK and HK isoforms may stimulate the respiratory chain and help to maintain energy homeostasis of chronically hypoxic myocardium and prevent oxidative stress
Permanent Link: http://hdl.handle.net/11104/0233266