Plzf as a Candidate Gene Predisposing the Spontaneously Hypertensive Rat to Hypertension, Left Ventricular Hypertrophy, and Interstitial Fibrosis

0427696 - FGÚ 2015 RIV GB eng J - Journal Article
Liška, F. - Mancini, M. - Krupková, M. - Chylíková, B. - Křenová, D. - Šeda, O. - Šilhavý, Jan - Mlejnek, Petr - Landa, Vladimír - Zídek, Václav - d´Amati, G. - Pravenec, Michal - Křen, Vladimír
Plzf as a Candidate Gene Predisposing the Spontaneously Hypertensive Rat to Hypertension, Left Ventricular Hypertrophy, and Interstitial Fibrosis.
American Journal of Hypertension. Roč. 27, č. 1 (2014), s. 99-106. ISSN 0895-7061. E-ISSN 1941-7225
R&D Projects: GA ČR(CZ) GAP301/10/0756; GA ČR(CZ) GAP301/12/0696; GA MŠMT(CZ) LL1204; GA MŠMT(CZ) 7E10067
Grant - others:Univerzita Karlova(CZ) PRVOUK-P25/LF1/2
Institutional support: RVO:67985823
Keywords : hypertension * left ventricular hypertrophy * myocardial interstitial fibrosis * spontaneously hypertensive rat * Plzf (promyelocytic leukemia zinc finger) gene
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.852, year: 2014

The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension, and is susceptible to left ventricular hypertrophy and myocardial fibrosis. Recently, a quantitative trait locus (QTL) influencing heart interstitial fibrosis was mapped to chromosome 8. Using detailed congenic mapping, we obtained compelling evidence for significant role of genetic factors in regulating blood pressure, LVH, and cardiac fibrosis and identify mutant Plzf as a prominent candidate gene
Permanent Link: http://hdl.handle.net/11104/0233209