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Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating
- 1.0427632 - FGÚ 2015 RIV CH eng J - Journal Article
Rokic, Milos Boro - Stojilkovic, S. S. - Zemková, Hana
Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.
Frontiers in Cellular Neuroscience. Roč. 8, Jan 29 (2014), s. 3. E-ISSN 1662-5102
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:Univerzita Karlova(CZ) 3446/2011
Institutional support: RVO:67985823
Keywords : ATP * cadmium * ion access * purinergic receptors * scanning mutagenesis
Subject RIV: ED - Physiology
Impact factor: 4.289, year: 2014
We used cysteine and alanine scanning mutagenesis of the rat P2X4R receptor V47-V61 and K326-N338 sequences to study structural and functional properties of extracellular vestibule during gating. The effect of cadmium on channel gating was stimulatory in the majority of reactive V47-V61 mutants and inhibitory in the majority of reactive K326-N338 mutants, which suggests opposite roles for these sequences in receptor gating
Permanent Link: http://hdl.handle.net/11104/0233131
Number of the records: 1